Anticholinergic activity of selected indigenous medicinal plants on sheep tracheal smooth muscle by organ bath studies was carried out. The anticholinergic activity of plant extracts was determined in-vitro by using organ bath in which sheep tracheal smooth muscle was mounted in Krebs-Henseleit solution and its contractile activity for acetylcholine, a known cholinergic spasmogen was recorded in the presence and absence of plant extracts to determine the anticholinergic potential of the extracts of indigenous plants. The percentile contractile response of acetylcholine in the presence and absence of tested plant extracts was recorded. Among the seven indigenous plants tested, acetone extracts of Amaranthus tricolor (leaf), Calotropis gigantean (leaf) and Sesbania grandiflora (leaf) revealed considerable anticholinergic property. The anticholinergic property of these extracts may be helpful in treatment of upper respiratory tract problems and bronchial asthma.
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